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Set 14 Smooth Muscle

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Question 1

(Multiple Choice)

Free
An increase in smooth muscle tension can occur at a given intracellular [Ca++] in response to:

A)Opening of K+ channels in the smooth muscle membrane.
B)Inhibition of myosin phosphatase by Rho kinase in the smooth muscle.
C)Cyclic adenosine monophosphate (cAMP)-dependent phosphorylation of myosin light-chain kinase in the smooth muscle.
D)Release of nitric oxide from adjacent endothelial cells.
E)Hyperpolarization of the smooth muscle membrane.

Answer

Question 2

(Multiple Choice)

Free
Endogenous agonists such as adenosine and prostacyclin,as well as β\beta 2-adrenergic receptor agonists,can elevate cAMP concentration in smooth muscle.The elevation of cAMP in the smooth muscle results in activation of cAMP-dependent signaling pathways in the smooth muscle.This activation typically:

A)Promotes relaxation,partly because of activation of myosin phosphatase.
B)Promotes contraction,partly because of activation of potassium channels.
C)Promotes relaxation,partly because of activation of Rho kinase.
D)Promotes contraction,partly because of inhibition of InsP3 production.
E)Promotes relaxation,partly because of inhibition potassium channels.

Answer

Question 3

(Multiple Choice)

Free
A variety of stimuli can elevate cyclic guanosine monophosphate (cGMP)concentration in smooth muscle,which results in activation of cGMP-dependent signaling pathways in the smooth muscle.This activation typically:

A)Promotes relaxation,partly because of inhibition of myosin phosphatase.
B)Promotes contraction,partly because of decreased endothelin production.
C)Promotes relaxation,partly because of activation of potassium channels .
D)Promotes contraction,partly because of inhibition of InsP3 production.
E)Promotes relaxation,partly because of activation of voltage-gated Ca channels.

Answer