Gout patients have high uric acid levels in their blood and suffer from arthritis in their joints as a result of formation of intracellular and extracellular uric acid crystals. Would you expect treatment with glucocorticoids (G), which inhibit prostaglandin synthesis, or with tumor necrosis factor (TNF) to be normally used to treat such patients?
If mice are injected with antibodies against selectin homing receptors or against the integrin ligand I-CAM1 (which is expressed on the surface of endothelial cells), they show immune defects, such as higher susceptibility to bacterial infections. Which of the following properties of lymphocytes at endothelial cells would you expect to observe after injection with both antibodies?
A) Normal lymphocyte rolling and normal lymphocyte adhesion B) Impaired lymphocyte rolling but normal lymphocyte adhesion C) Normal lymphocyte rolling but impaired lymphocyte adhesion D) Impaired lymphocyte rolling and impaired lymphocyte adhesion
Mice whose immune systems had previously rejected a tissue transplant from a certain strain of donor mouse received another transplant shortly afterward, either from the same donor strain or a new one. All of the recipient mice eventually rejected the transplant. However, one group did so more quickly than the other group. Do you think this group received the graft from the original mouse strain (O) or the new strain (N)? Write down O or N as your answer.