Fill in the blank: In the intrinsic pathway of apoptosis, a protein called ... is released from the mitochondria into the cytosol and binds to the adaptor protein Apaf1, causing it to oligomerize into a wheel-like assembly called an apoptosome, which then recruits initiator caspase-9 proteins.
Indicate true (T) and false (F) statements below regarding programmed cell death by apoptosis. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF. ( ) Apoptosis is the final fate of almost all cells in an adult animal. ( ) Even perfectly healthy cells may undergo apoptosis. ( ) DNA damage that cannot be repaired inhibits apoptotic pathways. ( ) Apoptosis is the main form of programmed cell death in plant cells as well as in animal cells.
Which of the following morphological changes is NOT typically seen in a cell that is undergoing apoptosis?
A) The cell rounds up. B) The nuclear envelope disassembles. C) The cell swells. D) Large cells break up into membrane-enclosed fragments. E) The nuclear chromatin breaks into fragments.