Fusion of the reading frames of the bcr and abl genes,as is often observed in cases of chronic myelogenous leukemia CML),is an example of what type of genetic alteration?
A)A reciprocal chromosomal translocation B)A nonreciprocal chromosomal translocation C)A frameshift mutation D)A chromosomal deletion E)None of the above
Which of the following consequences of mutations would be LEAST likely to be associated with an increased cancer risk?
A)Truncation of the EGF receptor B)Amplification of myc C)Amplification of ErbB2 D)Truncation of H-Ras due to a premature stop codon. E)Constitutive activation of K-Ras