Which of the following is characteristic of field cancerization?
A)A single tumor grows from a single mutant cell. B)Multiple tumors in an organ are separated by normal tissue. C)Multiple tumors in an organ share the same germ-line mutation. D)B and C. E)A,B,and C.
A)Inflammatory cells are often detected in tumor samples. B)Cancer often arises at sites of chronic inflammation. C)Use of NSAIDs has been associated with increased mortality from colorectal cancer. D)The inflammatory cytokine TNF has been shown to have direct transforming properties. E)Levels of macrophage infiltration in tumors have been negatively correlated with patient prognosis.