Course

Genetics

Study Pack

Set 12 Maintenance Of Genomic Integrity And The Development Of Cancer

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Question 1

(Multiple Choice)

Free
Which of the following is true of the BRCA1 gene?

A)Its product normally functions in DNA repair.
B)Germ-line mutations in this gene are associated with an increased risk for breast and ovarian cancers.
C)Somatic mutations in this gene are associated with an increased risk for ovarian cancer.
D)A,B,and C.
E)None of the above.

Answer

Question 2

(Multiple Choice)

Free
Which of the following may result in loss of function of a tumor suppressor gene?

A)Nondisjunction of sister chromatids
B)Failure of a chromatid containing a tumor suppressor gene to attach to a spindle fiber during cell division
C)Hypermethylation of the promoter for the gene
D)A,B,and C
E)None of the above

Answer

Question 3

(Multiple Choice)

Free
Keratoses,or benign skin lesions,often exhibit

A)Mutant p53 alleles.
B)Mutations carrying a dipyrimidine substitution.
C)Mutations resulting from exposure to UV light.
D)A,B,and C.
E)None of the above.

Answer