In observing DNA replication in the lab, you notice that in some cells, a defect occurs where DNA replication proceeds, but the RNA primers are not removed and replaced with DNA. Which enzyme is MOST likely to be defective in this system?
A)RNA primase B)helicase C)single-strand binding protein D)DNA polymerase E)DNA ligase
Consider a cell in which one of the proteins or enzymes involved in DNA replication is altered in a way that results in an increased rate of single-base changes in the newly synthesized DNA strand. Which function of which protein is MOST likely disrupted in this situation?
A)the unwinding function of helicase B)the winding stress relief function of topoisomerase II C)the fragment joining function of DNA ligase D)the proofreading function of DNA polymerase E)the strand separation function of single-stranded binding protein