Which of the following describes a difference between transcription and genome replication in the influenza virus?
A) Transcription requires the PB2 protein while genome replication does not. B) Transcription produces a shorter positive strand mRNA while replication produces a full-length antigenome. C) Transcription produces a poly(A) tail at the 3' end of the viral mRNA while genome replication does not. D) Transcription requires a primer derived from a cellular pre-mRNA while genome replication does not. E) All of the above are correct.
Cleavage of the HA protein of influenza by cellular proteases is important for which of the following?
A) Activation of the fusion peptide. B) Creation of the sialic acid binding site. C) Release of the envelope proteins from the Golgi. D) Attachment of the envelope to the capsid. E) Insertion of the HA protein into the membrane.
Treatment of influenza infected cells with actinomycin D and a-amanitin, which inhibit the activity of the cellular RNA polymerase II, shut down the synthesis of viral mRNAs.Which of the following describes the mechanism of this inhibition?
A) The viral RNA-dependent RNA polymerase is also inhibited by these compounds. B) The virus needs a supply of nuclear pre-mRNAs to snatch caps from. C) These inhibitors reduce the supply of nucleotides for transcription. D) The cellular RNA polymerase synthesizes the viral mRNAs. E) This leads to the degradation of the viral RNA genome segments.