Course

Biochemistry

Study Pack

Set 19 The Tricarboxylic Acid Cycle

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Question 1

(Multiple Choice)

Free
The two step reaction catalyzed by isocitrate dehydrogenase involves:
A.β-decarboxylation expelling the α-keto carboxyl as CO2.
B.oxidation of the C-2 alcohol of isocitrate to form oxalosuccinatE.
C.oxidation of the C-2 alcohol to form oxaloacetatE.
D.β-elimination expelling the central carboxyl group as CO2.

A) A and B
B) B and C
C) C and D
D) A and C
E) B and D

Answer

Question 2

(Multiple Choice)

Free
Order the coenzymes according to their involvement in the pyruvate dehydrogenase complex.
A.NAD+
B.CoA-SH
C.TPP
D.Lipoate (lipoamide)
E.[FAD]

A) A, B, C, D, E
B) C, B, A, E, D
C) C, D, B, E, A
D) B, D, E, A, C
E) C, E, D, B, A

Answer

Question 3

(Multiple Choice)

Free
Isocitrate dehydrogenase has all of the characteristics EXCEPT:

A) ADP raises the Km for isocitrate by a factor of 10.
B) virtually inactive in the absence of ADP.
C) sufficiently exergonic to pull the aconitase reaction forward.
D) allosterically inhibited by NADH and ATP.
E) an oxidative-decarboxylation reaction.

Answer