The two step reaction catalyzed by isocitrate dehydrogenase involves: A.β-decarboxylation expelling the α-keto carboxyl as CO2. B.oxidation of the C-2 alcohol of isocitrate to form oxalosuccinatE. C.oxidation of the C-2 alcohol to form oxaloacetatE. D.β-elimination expelling the central carboxyl group as CO2.
A) A and B B) B and C C) C and D D) A and C E) B and D
Isocitrate dehydrogenase has all of the characteristics EXCEPT:
A) ADP raises the Km for isocitrate by a factor of 10. B) virtually inactive in the absence of ADP. C) sufficiently exergonic to pull the aconitase reaction forward. D) allosterically inhibited by NADH and ATP. E) an oxidative-decarboxylation reaction.