Which of the Following Types of Mutations Would NOT Be

Question

Which of the following types of mutations would NOT be advantageous to a cancer cell? A)An inactivating mutation in pRb B)An inactivating mutation in a gene controlling a DNA damage checkpoint C)An inactivating mutation in p16^INK4A D)An inactivating mutation in cyclin D E)An inactivating mutation in p19^INK4D

Accepted Answer

Inactivating cyclin D, which promotes cell cycle progression, would not be advantageous to a cancer cell as it would slow down their proliferation. The other mutations listed all contribute to cancer development by promoting cell cycle progression or inhibiting DNA repair.