A)If UGA, usually a stop codon, is found to code for an amino acid such as tryptophan (usually coded for by UGG only).
B)If one stop codon, such as UGA, is found to have a different effect on translation than another stop codon, such as UAA.
C)If prokaryotic organisms are able to translate a eukaryotic mRNA and produce the same polypeptide.
D)If several codons are found to translate to the same amino acid, such as serine.
E)If a single mRNA molecule is found to translate to more than one polypeptide when there are two or more AUG sites.