A)bind to the active site of an enzyme through noncovalent bonds.
B)have only a temporary effect on enzyme activity.
C)are often toxic to cells.
D)are not active against ribozymes.
E)are uncommon in nature.

A)contains amino acids that are contiguous to one another along the primary sequence of the protein.
B)may require a prosthetic group such as a metal ion.
C)involves amino acids that are brought into close proximity by extensive protein folding.
D)usually depends on only one amino acid.
E)involves amino acids that are brought into close proximity by extensive protein folding and may require a prosthetic group such as a metal ion.

A)This state is composed of the difference in activation energy of a catalyzed versus an uncatalyzed reaction.
B)The metastable state is formed by transient complexes with the substrate.
C)The metastable state is created by the prosthetic group of the enzyme.
D)This state changes the position of the equilibrium but not the rate.
E)The metastable state is a state of the substrate in which the reaction can proceed but typically requires a catalyst.