Which of the following best describes a metastable state?

A)This state is composed of the difference in activation energy of a catalyzed versus an uncatalyzed reaction.
B)The metastable state is formed by transient complexes with the substrate.
C)The metastable state is created by the prosthetic group of the enzyme.
D)This state changes the position of the equilibrium but not the rate.
E)The metastable state is a state of the substrate in which the reaction can proceed but typically requires a catalyst.