A) there is an increase in entropy associated with protein folding.
B) there is a decrease in entropy of the solvent by burying hydrophobic groups within the molecule.
C) of the large negative enthalpy change associated with many noncovalent interactions.
D) no intermediate stage disulphide bonds form during the folding process.
E) all of the above.

A) They include a major class of protein that comprises hair, fingernails and animal skin.
B) Individual molecules are α-helical.
C) There is a strip of contiguous hydrophobic surface making a shallow spiral around the helix.
D) They include a small globular regions covalently linked to the surface.
E) Pairs of α-helices twist about each other in a coiled-coil structure held together entirely by hydrophobic interactions.