What is the Main Pathological Feature of Prion Diseases

Question

What is the main pathological feature of prion diseases?
A) Death of cells in the substantia nigra
B) Spongiform encephalitis
C) Amyloid plaques
D) Neurofibrillary tangles
E) The presence of Lewy bodies
F) Overexpression of presenilin

Accepted Answer

The main pathological feature of prion diseases is spongiform encephalitis, characterized by the presence of vacuoles or small cavities in the brain tissue. These vacuoles are caused by the accumulation of abnormal and infectious proteins, called prions. This leads to the degeneration and death of neuronal cells in the brain, resulting in the symptoms of prion diseases.