What Does This Tell You About the Relation Between These

Question

What does this tell you about the relation between these two gene products?
A) They are in independent pathways.
B) Parkin is downstream of Pink1.
C) Pink1 is downstream of Parkin.
D) Both gene products act on a common target.

Accepted Answer

Pink1 and Parkin are in a common pathway that regulates mitochondrial function and Pink1 is upstream up Parkin. Therefore, overexpressing Parkin will rescue the mutation as it is downstream of the Pink1 mutation.