Which of the Following May Result from Activation of TGF-β

Question

Which of the following may result from activation of TGF-β? A)Increased activation of cyclin D/CDK4/6 complexes B)Increased expression of p21^Cip1 in the cytoplasm of the cell C)Reduced expression of p15^I^NK4B D)Decreased activation of cyclin E/CDK2 complexes E)Phosphorylation of Smad4

Accepted Answer

TGF-β activation can lead to decreased activation of cyclin E/CDK2 complexes, which is part of its role in inhibiting cell cycle progression.