A) Eukaryotic protein-coding genes typically lack introns, so more sophisticated algorithms must be used to identify such genes.
B) Eukaryotic protein-coding genes typically have introns, so more sophisticated algorithms must be used to identify such genes.
C) Because many genes have introns in prokaryotic genomes, searching for protein-coding ORFs is straightforward.
D) Because many genes have introns in prokaryotic genomes, searching for protein-coding ORFs is very difficult.