A) when there is an increase in transmembrane potential.
B) if positive ions such as Ca2+ ions leak into the neuron.
C) if there is a decrease in number of intracellular potassium ions.
D) if positive ions such as Ca2+ ions leak into the neuron or when there is an increase in transmembrane potential.
E) if there is a decrease in number of intracellular potassium ions or when there is an increase in transmembrane potential .