The Consumption of Acetyl-CoA by the Citric Acid Cycle Is

Question

The consumption of acetyl-CoA by the citric acid cycle is DECREASED under which condition? A) the concentration of NAD⁺ being high B) the concentration of oxaloacetate being high C) NADH being rapidly re-oxidized via the electron-transport chain D) the mitochondrial ATP synthase being inactive E) the concentration of both NAD⁺ and oxaloacetate being high

Accepted Answer

When mitochondrial ATP synthase is inactive, ATP production is hindered, leading to a buildup of ADP and AMP. This signals the cell to decrease energy-consuming processes, including the citric acid cycle, thus reducing the consumption of acetyl-CoA.