Which Statement Regarding Oxidative Phosphorylation is TRUE

Question

Which statement regarding oxidative phosphorylation is TRUE?
A) The rate of electron transport is independent of the magnitude of the proton electrochemical gradient.
B) ATP synthase utilizes oxidized cofactors.
C) Proton transfer through the Fosubunit of ATP synthase is required in order for ATP synthesis to occur.
D) The addition of an uncoupler decreases the rate of re-oxidation of NADH and FADH2, therefore decreasing the rate of the citric acid cycle.
E) All of the statements are true.

Accepted Answer

Proton transfer through the F0 subunit of ATP synthase is required for ATP synthesis to occur. This subunit acts as a proton channel, allowing the flow of protons down their electrochemical gradient. The F1 subunit of ATP synthase then uses this energy to synthesize ATP. The other statements are false.