Which Statement is NOT True of the Reaction Producing Malonyl-CoA

Question

Which statement is NOT true of the reaction producing malonyl-CoA during fatty acid synthesis?
A) It is stimulated by citrate.
B) It requires acyl carrier protein (ACP).
C) It requires CO2(or bicarbonate).
D) One mole of ATP is converted to ADP + Pifor each malonyl-CoA synthesized.
E) The cofactor is biotin.

Accepted Answer

The reaction producing malonyl-CoA during fatty acid synthesis does not require acyl carrier protein (ACP); instead, it involves the enzyme acetyl-CoA carboxylase, which uses biotin as a cofactor and converts acetyl-CoA into malonyl-CoA, consuming ATP in the process and requiring bicarbonate as a substrate.