Which of the Following CORRECTLY Describes Nonsense Mutations

Question

Which of the following CORRECTLY describes nonsense mutations?
A)They cause a nonfunctional amino acid to replace a functional amino acid.
B)They change the nucleotide sequence of a gene but do not change the sequence of the resulting protein.
C)They result in the insertion or deletion of a small number of nucleotides to the DNA.
D)They convert a codon for a particular amino acid within a gene into a stop codon.
E)They cannot revert or back-mutate to wild-type.

Accepted Answer

Nonsense mutations convert a codon for a particular amino acid within a gene into a stop codon, causing premature termination of translation and a truncated protein. This results in loss of function or a nonfunctional protein.