The Philadelphia Chromosome Is

Question

The Philadelphia chromosome is:
A)an example of an aneuploidy.
B)the result of a translocated chromosome involving parts of chromosomes 9 and 22.
C)a lengthened version of chromosome 22 that results from a recombination event with chromosome 12.
D)a shortened version of chromosome 22 that results from a deletion.
E)a lengthened version of chromosome 22 that results from a duplication.

Accepted Answer

The Philadelphia chromosome is the result of a translocation between the long arms of chromosomes 9 and 22. Specifically, a piece of chromosome 9 (containing the ABL1 gene) is translocated to chromosome 22 and fused to another piece of chromosome 22 (containing the BCR gene). This fusion results in the creation of a new fusion gene, BCR-ABL1, which is associated with chronic myeloid leukemia (CML).