Transcription-Coupled Repair Usually Repairs the Template Strand

Question

Transcription-coupled repair usually repairs the template strand.

Accepted Answer

Transcription-coupled repair (TCR) is a DNA repair mechanism that operates during transcription to remove DNA lesions from the transcribed strand of active genes. This allows resumption of transcription and prevents the accumulation of mutations. TCR mostly repairs the template strand, which is the non-transcribed strand of the DNA double helix. Therefore, the statement is true.