Unlike All Other Amine Derived Hormones,thyroid Hormones

Question

Unlike all other amine derived hormones,thyroid hormones
A)bind to membrane receptors to elicit a response.
B)activate second messengers via binding to a membrane receptor.
C)are derived from cholesterol.
D)are produced by the gonads.
E)bind to intracellular receptors rather than to membrane-bound receptors to elicit a responsE.

Accepted Answer

Thyroid hormones bind to intracellular receptors, specifically thyroid hormone receptors (THR), located in the nucleus of the cell. The binding of the hormone to the receptor induces a conformational change in the receptor that allows it to bind to specific regions of DNA, resulting in the regulation of gene expression. This is different from other amine derived hormones, which typically bind to membrane receptors and activate second messenger systems. Thyroid hormones are also derived from the amino acid tyrosine, not cholesterol, and are not produced by the gonads.