The HIV1 Protease is a Good Target for Inhibiting Virus

Question

The HIV1 protease is a good target for inhibiting virus replication because…..
A) it cleaves the gag-pol polyprotein during virus assembly.
B) it is required for the maturation of HIV1 virus particles.
C) it has an unusual cleavage sequence on its substrate.
D) the crystal structure for the enzyme is available.
E) All of the above answers are correct.

Accepted Answer

The HIV1 protease is a good target for inhibiting virus replication because it cleaves the gag-pol polyprotein during virus assembly, it is required for the maturation of HIV1 virus particles, and it has an unusual cleavage sequence on its substrate. Additionally, the crystal structure for the enzyme is available. Therefore, all of the above answers are correct.