Which of the Following is NOT a Characteristic of the PrPᶜ

Question

Which of the following is NOT a characteristic of the PrPᶜ form of the prion protein?
A) It is bound to a phospholipid anchor.
B) It is synthesized in the rough ER.
C) It is glycosylated.
D) It binds to copper ions.
E) All of the above are characteristics of the PrPᶜ protein.

Accepted Answer

All the options listed (A, B, C, D) are indeed characteristics of the cellular prion protein (PrPᶜ). PrPᶜ is a cell surface glycoprotein that is anchored to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor, synthesized in the rough endoplasmic reticulum, undergoes glycosylation, and has the ability to bind copper ions.