Prions from one species do not easily cause prion diseases in animals of a different species.Which of the following may explain why?

A) The host cell needs to have the correct receptor for entry of the Prpˢᶜ protein.
B) The host needs to have the correct proteases for the proper processing of the PrPˢᶜ protein.
C) The host cell needs to provide the correct glycosylation pattern on the Prpˢᶜ protein.
D) The Prpˢᶜ protein needs to interact with a PrPᶜ protein with the same amino acid sequence.
E) There are other host related proteins involved in the development of a prion disease.