Which Component of the Adenovirus Virion Binds to the Host

Question

Which component of the adenovirus virion binds to the host cell receptor?
A) Knob on the fiber protein.
B) Penton base.
C) Hexons.
D) Minor capsid proteins.
E) Both "a" and "b" can bind to different receptors.

Accepted Answer

The knob on the fiber protein of adenovirus is primarily responsible for binding to the host cell receptor, facilitating the virus's attachment to the host cell. Additionally, the penton base, another component of the adenovirus, can also interact with host cell receptors, particularly integrins, aiding in the virus's internalization. Therefore, both components can bind to different receptors on the host cell.