Since translation of mRNAs in eukaryotic cells produces only a single polypeptide, how do picornaviruses produce multiple proteins from their RNA genome?

A) They produce multiple subgenomic mRNAs.
B) Their genome consists of a multicistronic mRNA.
C) They use multiple IRES regions to translate multiple open reading frames.
D) They have internal translation start sites in their genome.
E) They cleave a single polypeptide into individual proteins.