Translation Initiation of the Genomes of Picornaviruses Require All of the Following

Question

Translation initiation of the genomes of picornaviruses require all of the following EXCEPT:
A) IRES at the 5' end of the genome
B) VPg protein attached to 5' end of genome
C) Pyrimidine-rich sequence upstream of an AUG
D) Small subunit of ribosome
E) Host cell translation initiation factors

Accepted Answer

Picornaviruses do not require the VPg protein for translation initiation; instead, they use an internal ribosome entry site (IRES) at the 5' end of the genome to recruit the ribosome directly.