The Poliovirus Protease Cleaves the Cellular EIF-4G Protein

Question

The poliovirus protease cleaves the cellular eIF-4G protein.Why doesn't this affect the virus?
A) The virus doesn't use this protein as its host cell receptor.
B) The virus encodes the poly A tail as part of the genome.
C) The virus encodes its own version of this cellular protein.
D) The virus does not use cap-dependent translation.
E) The virus encodes its own RNA-dependent RNA polymerase.

Accepted Answer

The poliovirus does not rely on cap-dependent translation, which requires the eIF-4G protein for the initiation of translation. Instead, it uses an internal ribosome entry site (IRES) mechanism to initiate translation of its RNA, making the cleavage of eIF-4G irrelevant to its own protein synthesis.