Which of the Following Inhibitors is Effective as a Transition-State

Question

Which of the following inhibitors is effective as a transition-state analog?
A)competitive
B)non-competitive
C)allosteric
D)irreversible

Accepted Answer

Competitive inhibitors can act as transition-state analogs because they often mimic the substrate's structure and bind to the active site of the enzyme, effectively competing with the substrate for binding. This is characteristic of transition-state analogs, which are designed to resemble the transition state of a substrate in an enzyme-catalyzed reaction, thereby inhibiting the enzyme by stabilizing the enzyme-transition state complex.