Stabilization of LTP Depends on the Regulation of Actin Dynamics

Question

Stabilization of LTP depends on the regulation of actin dynamics.

Accepted Answer

Actin dynamics play a crucial role in the stabilization of long-term potentiation (LTP) in neurons. The remodeling of actin filaments is required for the growth and maturation of dendritic spines, which are the sites of most excitatory synapses in the brain. Disrupting actin dynamics can impair the maintenance of LTP and lead to cognitive deficits.