Which of the Following Contradicts the One-Gene,one-Enzyme Hypothesis

Question

Which of the following contradicts the one-gene,one-enzyme hypothesis?
A)A mutation in a single gene can result in a defective protein.
B)Alkaptonuria results when individuals lack a single enzyme involved in the catalysis of homogentisic acid.
C)Sickle-cell anemia results in defective hemoglobin.
D)A single antibody gene can code for different related proteins, depending on the splicing that takes place post-transcriptionally.
E)Two enzymes are able to metabolize the same reaction.

Accepted Answer

The one-gene, one-enzyme hypothesis suggests that each gene encodes a single enzyme. However, option D contradicts this by indicating that a single gene can produce different proteins through alternative splicing, which means one gene can lead to multiple protein products.