Which of the Following Mutations is Most Likely to Cause

Question

Which of the following mutations is most likely to cause a phenotypic change?
A)a duplication of all or most introns
B)a large inversion whose ends are each in intergenic regions
C)a nucleotide substitution in an exon coding for a transmembrane domain
D)a single nucleotide deletion in an exon coding for an active site
E)a frameshift mutation one codon away from the 3' end of the nontemplate strand

Accepted Answer

A single nucleotide deletion in an exon coding for an active site is most likely to cause a phenotypic change because it can directly affect the protein's function by altering its active site, potentially leading to a loss or change in function.