Mammals produce five major classes of immunoglobulins. Indicate whether each of the following descriptions better applies to the immunoglobulin A, D, E, G, or M class. Your answer would be a five-letter string composed of letters A, D, E, G, and M only, e.g. GMADE. ( ) It binds to cells that secrete histamine. ( ) It is the major antibody in secretions such as saliva. ( ) It is the major antibody circulating in the blood. ( ) It is found on the surface of naïve B cells along with IgM. ( ) It forms wheel-like pentamers involved in the primary immune response.