Indicate whether each of the following mutations would likely promote (P) or inhibit (I) apoptosis in cells harboring the mutation(s). Your answer would be a four-letter string composed of letters P and I only, e.g. PPPI.
( ) Mutations in the pro-apoptotic effector Bcl2 family proteins Bax and Bak that prevent their association with the outer mitochondrial membrane.
( ) A mutation in the BIR domain of the IAP protein DIAP1 that prevents binding to either caspases or anti-IAP proteins.
( ) A mutation in the anti-IAP protein Reaper that prevents its binding to the IAP proteins.
( ) A mutation in the CARD domain of caspase-9 that prevents its binding to Apaf1.