In the Presence of an ATP Analog That Can Bind

Question

In the presence of an ATP analog that can bind myosin normally but cannot be hydrolyzed, …
A) a myosin cannot bind tightly to an actin filament and cannot move on it.
B) a myosin cannot be released from an actin filament and cannot move on it.
C) a myosin performs the power stroke but cannot be released from an actin filament.
D) a myosin performs the power stroke but cannot bind tightly to an actin filament.
E) a myosin is able to perform normally.

Accepted Answer

The power stroke and tight binding to the actin filament require ATP hydrolysis and inorganic phosphate (Pᵢ) release. However, the release of myosin from the actin filament only requires ATP binding.