How does the expression of Delta on the surface of a cell activate the expression of certain genes in the nucleus of its neighboring cell?

A) Delta binding activates Notch, which activates a transcriptional activator through the JAK-STAT pathway.
B) Delta binding leads to the stabilization of a cytoskeleton-associated transcriptional activator.
C) Delta binding releases the intracellular tail of Notch, which enters the nucleus and converts a transcriptional repressor into a transcriptional activator.
D) Delta binding leads to Notch-mediated recruitment of protein complexes to the plasma membrane, resulting in the degradation of a transcriptional repressor.
E) Delta binding leads to the proteolytic cleavage of Notch and inhibition of its activity as a transcriptional repressor, leading to the activation of target genes.