Indicate true (T) and false (F) statements below regarding the ubiquitin ligase c-Cbl. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( ) It contains an SH2 domain, and can therefore activate RTK signaling.
( ) It ubiquitylates activated RTKs.
( ) Its overactivation can lead to prolonged RTK signaling and promote the development of cancer.
( ) It is part of a negative feedback loop to down-regulate RTKs.