Which of the Following Events Normally Activates a GTP-Binding Protein

Question

Which of the following events normally activates a GTP-binding protein?
A) GTP hydrolysis by the protein
B) Activation of an upstream GTPase-activating protein
C) Activation of an upstream guanine nucleotide exchange factor
D) Phosphorylation of a bound GDP molecule by an upstream phosphorylase
E) Pᵢ release after GTP hydrolysis

Accepted Answer

Activation of an upstream guanine nucleotide exchange factor (GEF) activates a GTPase by facilitating its conversion into a GTP-bound form through guanine nucleotide exchange.