Misfolded Proteins in the ER May Actively Undergo Any of the Following

Question

Misfolded proteins in the ER may actively undergo any of the following EXCEPT ...
A) binding to chaperones such as BiP to allow unfolding and refolding.
B) binding to chaperones such as calnexin to prevent aggregation.
C) being transported back to the cytosol for degradation.
D) being expelled to the Golgi apparatus for disposal.
E) being glycosylated and binding to lectins.

Accepted Answer

Misfolded proteins are carefully monitored by the ER quality control system and are prevented from advancing in the secretory pathways for as long as they are not correctly folded.