For a Complementation Test to Work, the Mutations Under Study

Question

For a complementation test to work, the mutations under study must be…
A) recessive.
B) dominant.
C) gain-of-function.
D) null.
E) conditional.

Accepted Answer

If the mutations are recessive, a complementation test can be used to ascertain whether the mutations fall in the same gene or in different genes. Note that most recessive mutations are partial or complete loss-of-function (that is, null) mutations.