As point of care (POC) tests are developed, two concerns are sensitivity and specificity. Which of the following statements are true with respect to these terms?

A) Sensitivity deals with how much you can dilute the sample to get a result, whereas specificity deals with how much you dilute a control serum to get a result.
B) Sensitivity deals with how many false positives you get, whereas specificity deals with false negatives.
C) Sensitivity deals with distinguishing between closely related samples such as group A Streptococcus versus group B Streptococcus. Specificity quantitates those differences.
D) Sensitivity deals with how often a test is positive when the patient has the disease, whereas specificity deals with how often the test is negative when the patient does not have the disease.
E) The sensitivity and specificity of a test must be confirmatory or the test is useless.