All Oxidative Catabolism of Toluene and Other Benzene Derivatives Proceeds

Question

All oxidative catabolism of toluene and other benzene derivatives proceeds through
A) benzoyl-S-CoA.
B) aniline.
C) catechols.
D) cis, cis-muconate.
E) D-gluconate.

Accepted Answer

The oxidative catabolism of toluene and other benzene derivatives proceeds through catechols. These compounds are formed through the initial attack of a monooxygenase enzyme on the aromatic ring, which introduces a hydroxyl group. Further oxidation leads to the formation of catechols, which are then metabolized through various pathways.

Answer: A
 Benzoyl-S-CoA is an intermediate in the degradation of aromatic compounds like toluene. It is formed through the action of a CoA ligase enzyme, which activates benzoyl acid by attaching it to coenzyme A (CoA). This intermediate can then be further metabolized through the beta-oxidation pathway.

Answer: D
 Cis, cis-muconate is an intermediate in the degradation of aromatic compounds like toluene. It is formed from catechols through the action of a meta-cleavage enzyme. Cis, cis-muconate can then be further metabolized through the beta-oxidation pathway.

Option B and E are incorrect as aniline and D-gluconate are not intermediates in the oxidative catabolism of toluene and other benzene derivatives.