Which of the following is evidence that the Entner-Doudoroff (ED) route might have evolved earlier than the Embden-Meyerhof-Parnas pathway (EMP)?
A) ED involves a larger number of reactions and produces more energy and reducing equivalents with respect to EMP. B) 6-phosphogluconate is dehydrated to form pyruvate and glyceraldehyde 3-phosphate, which may then reenter the EMP pathway. C) ED involves fewer substrate-level phosphorylations and yields less energy and fewer reductants than EMP. D) They are both used to catabolize glucose. E) They both use ATP to phosphorylate glucose.