When studying an enzymatic reaction, should one consider $$\Delta$$ G, $$\Delta$$ G?, or $$\Delta$$ G?' when considering the thermodynamics of the reaction, and why?

A) $$\Delta$$ G⁰, because it considers standard conditions as well as biochemically relevant conditions such as the concentrations of substrates and products
B) $$\Delta$$ G⁰, because it considers standard conditions
C) $$\Delta$$ G, because it considers defined conditions such as pH
D) $$\Delta$$ G, because it considers concentrations of reactants as products.
E) $$\Delta$$ G⁰, because it considers entropy and enthalpy.