What Would You Expect to Find Bound to the Stop

Question

What would you expect to find bound to the stop codon at the A site?
A) a charged tRNA with the anticodon ATC
B) a charged tRNA with the anticodon TAG
C) an uncharged tRNA
D) a translation release factor
E) Nothing binds to a stop codon, which is why the peptide is released.

Accepted Answer

A translation release factor recognizes the stop codon at the A site of the ribosome, leading to the termination of translation and release of the newly synthesized polypeptide chain. Charged tRNAs correspond to codons that code for amino acids, not stop codons, and uncharged tRNAs or nothing at all binding to the stop codon are incorrect interpretations of the translation termination process.